Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.55 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 9/20 | 0.52 |
| ▸ | THRB | P10828 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 7/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2594552 | 0.91 | HCRTR1 (0.52) | L3MBTL1HCRTR1HCRTR2POLBTHRB | |
| SCHEMBL2592524 | 0.90 | POLB (0.53) | L3MBTL1HCRTR1HCRTR2POLBTHRB | |
| SCHEMBL2588315 | 0.89 | L3MBTL1 (0.65) | L3MBTL1HCRTR1HCRTR2POLBTHRB | |
| SCHEMBL2596039 | 0.79 | HCRTR1 (0.54) | L3MBTL1HCRTR1HCRTR2POLBTHRB | |
| SCHEMBL2592644 | 0.78 | HCRTR1 (0.70) | L3MBTL1HCRTR1HCRTR2POLBTHRB | |
| SCHEMBL2592992 | 0.78 | ATM (0.57) | L3MBTL1HCRTR1HCRTR2POLBTHRB | |
| SCHEMBL27249973 | 0.77 | L3MBTL1 (1.00) | L3MBTL1HCRTR1HCRTR2POLBTHRB | |
| SCHEMBL2588313 | 0.74 | HCRTR1 (0.76) | L3MBTL1HCRTR1HCRTR2POLBTHRB | |
| SCHEMBL2592510 | 0.73 | L3MBTL1 (0.70) | L3MBTL1HCRTR1HCRTR2POLBTHRB | |
| SCHEMBL1858950 | 0.73 | KDM4E (0.41) | L3MBTL1POLBMAPTLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011138265-A2 | INDOLE AND INDAZOLE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |