Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 3/20 | 0.39 |
| ▸ | BRD4 | O60885 | 8/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | MERTK | Q12866 | 1/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | MAP3K7 | O43318 | 3/20 | 0.35 |
| ▸ | TAB1 | Q15750 | 3/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25928954 | 0.89 | MET (0.39) | METBRD4AXLMERTKPTPN11 | |
| SCHEMBL25927369 | 0.87 | BRD4 (0.37) | METBRD4AXLMERTKPTPN11 | |
| SCHEMBL25930808 | 0.82 | MET (0.37) | METBRD4AXLMERTKPTPN11 | |
| SCHEMBL25928430 | 0.82 | MET (0.37) | METBRD4AXLMERTKPTPN11 | |
| SCHEMBL25927636 | 0.82 | JAK2 (0.35) | METBRD4AXLMERTKIRAK4 | |
| SCHEMBL25924810 | 0.82 | MET (0.40) | METBRD4AXLMERTKMAP3K7 | |
| SCHEMBL25930106 | 0.82 | MET (0.37) | METBRD4AXLMERTKPTPN11 | |
| SCHEMBL25929297 | 0.79 | HTR6 (0.40) | METBRD4AXLMERTKPTPN11 | |
| SCHEMBL25922895 | 0.78 | MAPK8 (0.46) | METIRAK4PDPK1PIK3CDPIK3CA | |
| SCHEMBL25927872 | 0.78 | JAK2 (0.38) | METBRD4AXLMERTKIRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023131271-A1 | PYRROLE FUSED-RING PYRAZOLE COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 杭州中美华东制药有限公司 | 2023-07-13 | — | — | WO | disclosed |