Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 6/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | MAP3K7 | O43318 | 4/20 | 0.34 |
| ▸ | TAB1 | Q15750 | 4/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.33 |
| ▸ | MERTK | Q12866 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.33 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.33 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25928954 | 0.87 | MET (0.39) | METBRD4IRAK4MAP3K7TAB1 | |
| SCHEMBL25927369 | 0.86 | BRD4 (0.37) | METBRD4IRAK4MAP3K7TAB1 | |
| SCHEMBL25930106 | 0.85 | MET (0.37) | METBRD4MAP3K7TAB1PIK3CA | |
| SCHEMBL25927465 | 0.82 | MET (0.39) | METBRD4IRAK4MAP3K7TAB1 | |
| SCHEMBL25927872 | 0.82 | JAK2 (0.38) | METBRD4IRAK4MAP3K7TAB1 | |
| SCHEMBL25927780 | 0.80 | JAK2 (0.37) | METBRD4MAP3K7TAB1PIK3CA | |
| SCHEMBL25923119 | 0.79 | PDPK1 (0.45) | METIRAK4PIK3CA | |
| SCHEMBL25930808 | 0.79 | MET (0.37) | METBRD4MAP3K7TAB1AXL | |
| SCHEMBL25924810 | 0.79 | MET (0.40) | METBRD4MAP3K7TAB1AXL | |
| SCHEMBL25932661 | 0.78 | ABL1 (0.38) | METMAP3K7TAB1PIK3CAJAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023131271-A1 | PYRROLE FUSED-RING PYRAZOLE COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 杭州中美华东制药有限公司 | 2023-07-13 | — | — | WO | disclosed |