Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 8/20 | 0.47 |
| ▸ | YAP1 | P46937 | 3/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | AMPD2 | Q01433 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.39 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31306775 | 0.89 | PRMT5 (0.46) | PRMT5YAP1GPR119NR4A2MAOB | |
| SCHEMBL8195218 | 0.80 | NAMPT (0.57) | PRMT5YAP1GPR119 | |
| SCHEMBL2160148 | 0.79 | MEN1 (0.46) | — | |
| SCHEMBL25936712 | 0.78 | NAMPT (0.50) | PRMT5YAP1GPR119 | |
| SCHEMBL16874689 | 0.77 | PRMT5 (0.50) | PRMT5YAP1GPR119LTA4H | |
| SCHEMBL29197711 | 0.74 | PRMT5 (0.38) | PRMT5GPR119OPRD1OPRK1 | |
| SCHEMBL25845395 | 0.74 | PRMT5 (0.49) | PRMT5YAP1GPR119NR4A2MAOB | |
| SCHEMBL20475182 | 0.73 | PRMT5 (0.48) | PRMT5YAP1GPR119NR4A2MAOB | |
| SCHEMBL21877176 | 0.73 | YAP1 (0.52) | PRMT5YAP1GPR119MAOBLTA4H | |
| SCHEMBL31639554 | 0.73 | NR1H2 (0.45) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118574821-A | Compounds and their use in the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-08-30 | — | — | CN | disclosed |
| WO-2023139199-A1 | COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2023-07-27 | — | — | WO | disclosed |