Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM8 | O00222 | 2/20 | 0.69 |
| ▸ | GRM6 | O15303 | 2/20 | 0.69 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.69 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.69 |
| ▸ | GSR | P00390 | 2/20 | 0.69 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.69 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.69 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.69 |
| ▸ | GRM5 | P41594 | 1/20 | 0.69 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.69 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.69 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.69 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.69 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.69 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.69 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.69 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.69 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.69 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| D-Glutamate SCHEMBL9474068 | 1.00 | GRM8 (0.69) | GRM8GRM6GRM7GRM4GSR | |
| D-Glutamate SCHEMBL1469787 | 0.94 | GRM8 (0.67) | GRM8GRM6GRM7GRM4GSR | |
| D-Glutamate SCHEMBL1470464 | 0.90 | GRM8 (0.72) | GRM8GRM6GRM7GRM4GSR | |
| Glutamic Acid SCHEMBL31507089 | 0.85 | GRM8 (0.95) | GRM8GRM6GRM7GRM4GSR | |
| Glutamic Acid SCHEMBL7294273 | 0.85 | GRM8 (0.95) | GRM8GRM6GRM7GRM4GSR | |
| D-Glutamate SCHEMBL28296939 | 0.85 | GRM8 (0.95) | GRM8GRM6GRM7GRM4GSR | |
| D-Glutamate SCHEMBL7294270 | 0.85 | GRM8 (0.95) | GRM8GRM6GRM7GRM4GSR | |
| Glutamic Acid SCHEMBL30195410 | 0.84 | GRM8 (0.75) | GRM8GRM6GRM7GRM4GSR | |
| SCHEMBL2722969 | 0.84 | GSR (0.56) | GRM8GRM6GRM7GRM4GSR | |
| SCHEMBL198242 | 0.84 | GSR (0.56) | GRM8GRM6GRM7GRM4GSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130190788-A1 | METHODS AND COMPOSITIONS FOR REPAIR OF VASCULAR TISSUE | COVALENT MEDICALS INC (US) | 2013-07-25 | — | — | US | disclosed |
| US-8252747-B2 | Tissue adhesive sealant | LOWINGER JOHAN (US) | 2012-08-28 | — | — | US | disclosed |
| WO-2011139781-A2 | METHODS AND COMPOSITIONS FOR REPAIR OF VASCULAR TISSUE | COVALENT MEDICAL, INC. (US) | 2011-11-10 | — | — | WO | disclosed |
| US-20090287313-A1 | TISSUE ADHESIVE SEALANT | LOWINGER JOHAN | 2009-11-19 | — | — | US | disclosed |
| US-7129210-B2 | Tissue adhesive sealant | COVALENT MEDICAL, INC. (US) | 2006-10-31 | — | — | US | disclosed |
| EP-1651038-A2 | TISSUE ADHESIVE SEALANT | Covalent Medical, Inc. (US) | 2006-05-03 | — | — | EP | disclosed |
| US-20050069589-A1 | Tissue adhesive sealant | COVALENT MEDICAL, INC. | 2005-03-31 | — | — | US | disclosed |
| WO-2005009225-A2 | TISSUE ADHESIVE SEALANT | COVALENT MEDICAL, INC. (US) | 2005-02-03 | — | — | WO | disclosed |
| US-5188834-A | Fixing with aldehyde, treating with aminodicarboxylic acid in buffered acidic solution to bind excess aldehyde | SORIN BIOMEDICA S.P.A. (IT) | 1993-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050069589-A1 | Tissue adhesive sealant | ICAM1, VCAM1, PLOD3 | GRM8 650/4885GRM6 945/4885GRM7 854/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.