SCHEMBL2593271

SCHEMBL2593271

Cc1nc(C2CCCCC2C(=O)NN)sc1Cl

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.36
RAB9A P51151 2/20 0.36
NPC1 O15118 1/20 0.36
ALDH1A1 P00352 4/20 0.35
CYP1A2 P05177 1/20 0.35
CYP3A4 P08684 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
CHRM4 P08173 3/20 0.33
LMNA P02545 1/20 0.32
MEN1 O00255 2/20 0.31
KMT2A Q03164 2/20 0.31
POLB P06746 1/20 0.31
CASP6 P55212 1/20 0.31
GAA P10253 1/20 0.31
CHRM2 P08172 1/20 0.30
CHRM1 P11229 1/20 0.30
KCNQ3 O43525 1/20 0.30
KCNQ2 O43526 1/20 0.30
GRM4 Q14833 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2596234 0.86 SMN1; SMN2 (0.47) SMN1; SMN2RAB9ANPC1ALDH1A1CYP1A2
SCHEMBL2595504 0.78 PDK1 (0.38) ALDH1A1CYP2C19
SCHEMBL2586046 0.77 AHR (0.38) SMN1; SMN2RAB9ANPC1ALDH1A1LMNA
SCHEMBL2589850 0.77 ALDH1A1 (0.38) SMN1; SMN2RAB9ANPC1ALDH1A1CYP1A2
SCHEMBL2586044 0.77 AHR (0.38) SMN1; SMN2RAB9ANPC1ALDH1A1LMNA
SCHEMBL2595970 0.71 ALDH1A1 (0.35) SMN1; SMN2RAB9ANPC1ALDH1A1CYP1A2
SCHEMBL2596228 0.69 SMN1; SMN2 (0.35) SMN1; SMN2ALDH1A1CYP1A2CYP3A4CYP2C9
SCHEMBL2595298 0.69 SMN1; SMN2 (0.36) SMN1; SMN2ALDH1A1CYP1A2CYP3A4CYP2C9
SCHEMBL2595265 0.69 CHRM2 (0.40) SMN1; SMN2ALDH1A1CYP1A2CYP3A4CYP2C9
SCHEMBL2595542 0.67 ALDH1A1 (0.36) SMN1; SMN2ALDH1A1CYP1A2CYP3A4CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2569319-A1 HETEROARYL-CYCLOHEXYL-TETRAAZABENZO[E]AZULENES F.HOFFMANN-LA ROCHE AG (CH) 2013-03-20 EP disclosed
WO-2011141396-A1 HETEROARYL-CYCLOHEXYL-TETRAAZABENZO[E]AZULENES F. HOFFMANN-LA ROCHE AG (CH) 2011-11-17 WO disclosed