SCHEMBL2595542

SCHEMBL2595542

Cc1nnc(C2CCCCC2C(=O)NN)o1

nearest known ligand 0.39

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.36
CYP1A2 P05177 1/20 0.36
CYP3A4 P08684 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
CCR5 P51681 1/20 0.34
KCNQ3 O43525 1/20 0.34
KCNQ2 O43526 1/20 0.34
ADCY1 Q08828 2/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
KDM5A P29375 1/20 0.31
ADCY8 P40145 1/20 0.30
HSD11B1 P28845 1/20 0.30
MEN1 O00255 1/20 0.30
KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2596230 0.81 SLC6A2 (0.44) CCR5ADCY1HSD11B1
SCHEMBL2595265 0.76 CHRM2 (0.40) ALDH1A1CYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL2582608 0.74 CCR5 (0.42) CCR5ADCY1ADCY8HSD11B1
SCHEMBL2582607 0.74 CCR5 (0.42) CCR5ADCY1ADCY8HSD11B1
SCHEMBL2595298 0.73 SMN1; SMN2 (0.36) ALDH1A1CYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL2595492 0.70 SMN1; SMN2 (0.36) ALDH1A1CYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL2596234 0.69 SMN1; SMN2 (0.47) ALDH1A1CYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL2596210 0.69 SMN1; SMN2 (0.35) ALDH1A1CYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL2596228 0.69 SMN1; SMN2 (0.35) ALDH1A1CYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL3623530 0.68 ALDH1A1 (0.45) ALDH1A1CYP1A2CYP3A4CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2569319-A1 HETEROARYL-CYCLOHEXYL-TETRAAZABENZO[E]AZULENES F.HOFFMANN-LA ROCHE AG (CH) 2013-03-20 EP disclosed
WO-2011141396-A1 HETEROARYL-CYCLOHEXYL-TETRAAZABENZO[E]AZULENES F. HOFFMANN-LA ROCHE AG (CH) 2011-11-17 WO disclosed