Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ATP4A | P20648 | 1/20 | 0.35 |
| ▸ | ATP4B | P51164 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24978007 | 0.87 | DGAT1 (0.47) | DGAT1L3MBTL1NR1H2NR1H3ALDH1A1 | |
| SCHEMBL2487182 | 0.86 | PIN1 (0.49) | DGAT1L3MBTL1NR1H2NR1H3ALDH1A1 | |
| SCHEMBL25482311 | 0.83 | DGAT1 (0.46) | DGAT1L3MBTL1NR1H2NR1H3ALDH1A1 | |
| SCHEMBL19585801 | 0.81 | DGAT1 (0.46) | DGAT1L3MBTL1NR1H2NR1H3ALDH1A1 | |
| SCHEMBL29532520 | 0.81 | DGAT1 (0.46) | DGAT1L3MBTL1NR1H2NR1H3ALDH1A1 | |
| SCHEMBL1360465 | 0.77 | DGAT1 (0.47) | DGAT1L3MBTL1NR1H2NR1H3ALDH1A1 | |
| SCHEMBL18301360 | 0.77 | DGAT1 (0.47) | DGAT1L3MBTL1NR1H2NR1H3ALDH1A1 | |
| SCHEMBL2673894 | 0.76 | L3MBTL1 (0.42) | DGAT1L3MBTL1NR1H2NR1H3ALDH1A1 | |
| SCHEMBL26447438 | 0.75 | DGAT1 (0.46) | DGAT1L3MBTL1ALDH1A1GAAMAPK1 | |
| SCHEMBL25447041 | 0.75 | DGAT1 (0.43) | DGAT1L3MBTL1NR1H2NR1H3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230242541-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | UPPTHERA, INC. (KR) | 2023-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230242541-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | PLK1, BUB1B, BUB1 | DGAT1 2465/4885L3MBTL1 964/4885NR1H2 2448/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.