Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 4/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 4/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11444335 | 0.80 | ALDH2 (0.55) | DDB1CRBNGAATSHR | |
| SCHEMBL25819902 | 0.80 | DDB1 (0.44) | DDB1CRBNSMN1; SMN2NPC1 | |
| SCHEMBL12676475 | 0.79 | MAPT (0.57) | NPSR1KDM4EALDH1A1GAAMEN1 | |
| SCHEMBL14492201 | 0.79 | MAP1LC3B (0.50) | DDB1CRBNTHRBNPSR1ALDH1A1 | |
| SCHEMBL8287037 | 0.77 | MAPK1 (0.54) | CRBNALDH1A1PIM1PIM2TSHR | |
| SCHEMBL1673541 | 0.75 | LMNA (0.49) | CRBNALDH1A1GAAMEN1MAPT | |
| SCHEMBL14492200 | 0.75 | GSK3B (0.53) | DDB1CRBNALDH1A1PIM1GAA | |
| SCHEMBL1859440 | 0.75 | CYP19A1 (0.61) | DDB1CRBNGAATSHRMAPT | |
| SCHEMBL28287533 | 0.75 | ALDH1A1 (0.53) | NPSR1KDM4EALDH1A1PIM1MAPT | |
| SCHEMBL14492202 | 0.74 | ALDH1A1 (0.55) | DDB1CRBNKDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230242541-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | UPPTHERA, INC. (KR) | 2023-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230242541-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | PLK1, BUB1B, BUB1 | DDB1 132/4885CRBN 2136/4885THRB 3153/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.