Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 2/20 | 0.48 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 2/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | CASP2 | P42575 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.41 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25937263 | 0.89 | ALDH1A1 (0.60) | ALDH1A1POLBKDM4EHPGDCASP3 | |
| SCHEMBL30557526 | 0.89 | ALDH1A1 (0.60) | ALDH1A1POLBKDM4EHPGDCASP3 | |
| SCHEMBL25430623 | 0.83 | ALDH1A1 (0.55) | ALDH1A1POLBKDM4EHPGDBRD4 | |
| SCHEMBL30557602 | 0.82 | NOTUM (0.56) | ALDH1A1SIGMAR1KMT2AMEN1RAB9A | |
| SCHEMBL31033163 | 0.81 | BRD4 (0.52) | DDB1CRBNALDH1A1BRD4CASP3 | |
| SCHEMBL29730857 | 0.78 | BRD4 (0.53) | CRBNALDH1A1BRD4RAB9ASMN1; SMN2 | |
| SCHEMBL30557529 | 0.77 | GRM7 (0.57) | ALDH1A1POLBKDM4EKMT2AMEN1 | |
| SCHEMBL3103616 | 0.77 | GRM7 (0.57) | ALDH1A1POLBKDM4EKMT2AMEN1 | |
| SCHEMBL30557604 | 0.76 | CTSL (0.53) | ALDH1A1POLBKDM4EKMT2AMEN1 | |
| SCHEMBL25937370 | 0.76 | BRD4 (0.56) | ALDH1A1KDM4EBRD4CASP3CASP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023144793-A1 | POL THETA INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-08-03 | — | — | WO | disclosed |
| WO-2023144793-A1 | POL THETA INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-08-03 | — | — | WO | disclosed |