Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 6/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.39 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25937726 | 0.85 | DPP8 (0.40) | SIGMAR1DRD2NOTUMNAMPTLMNA | |
| SCHEMBL30557602 | 0.85 | NOTUM (0.56) | SIGMAR1CTSLNOTUMLMNACYP3A4 | |
| SCHEMBL3103616 | 0.83 | GRM7 (0.57) | CTSLNOTUMALDH1A1GRM7TSHR | |
| SCHEMBL30557529 | 0.83 | GRM7 (0.57) | CTSLNOTUMALDH1A1GRM7TSHR | |
| SCHEMBL25428357 | 0.82 | ALDH1A1 (0.47) | NOTUMLMNACYP3A4L3MBTL1ALDH1A1 | |
| SCHEMBL25937424 | 0.82 | NOTUM (0.53) | SIGMAR1DRD2NOTUMLMNACYP3A4 | |
| SCHEMBL30557604 | 0.82 | CTSL (0.53) | CTSLNOTUMLMNAALDH1A1GRM7 | |
| SCHEMBL23834391 | 0.80 | PPARA (0.42) | CTSL | |
| SCHEMBL23834389 | 0.80 | PPARA (0.42) | CTSL | |
| SCHEMBL25508275 | 0.79 | CTSL (0.42) | CTSLNOTUMTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023144793-A1 | POL THETA INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-08-03 | — | — | WO | disclosed |
| WO-2023144793-A1 | POL THETA INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-08-03 | — | — | WO | disclosed |