Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 2/20 | 0.37 |
| ▸ | PER2 | O15055 | 1/20 | 0.36 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25937485 | 0.85 | SIGMAR1 (0.45) | NOTUMSIGMAR1CYP3A4NAMPTALDH1A1 | |
| SCHEMBL25937382 | 0.84 | BRD4 (0.48) | DPP8DPP9NOTUMSIGMAR1KCNQ2 | |
| SCHEMBL30557646 | 0.84 | BRD4 (0.48) | DPP8DPP9NOTUMSIGMAR1KCNQ2 | |
| SCHEMBL25430638 | 0.84 | PIK3CD (0.43) | NOTUMPIK3CDCYP3A4PIK3CBPIK3CA | |
| SCHEMBL25937403 | 0.83 | KCNQ2 (0.41) | SIGMAR1KCNQ2MEN1KMT2AALDH1A1 | |
| SCHEMBL25937545 | 0.80 | KCNQ2 (0.46) | SIGMAR1KCNQ2MEN1KMT2AALDH1A1 | |
| SCHEMBL30557580 | 0.80 | KCNQ2 (0.46) | SIGMAR1KCNQ2MEN1KMT2AALDH1A1 | |
| SCHEMBL25937565 | 0.78 | KCNQ2 (0.40) | SIGMAR1KCNQ2MEN1KMT2AALDH1A1 | |
| SCHEMBL25937732 | 0.77 | AKT1 (0.47) | NOTUMPIK3CDCYP3A4PIK3CBPIK3CA | |
| SCHEMBL25937707 | 0.76 | BRD4 (0.39) | DPP8DPP9SIGMAR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023144793-A1 | POL THETA INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-08-03 | — | — | WO | disclosed |
| WO-2023144793-A1 | POL THETA INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-08-03 | — | — | WO | disclosed |