Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ2 | O43526 | 2/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.38 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.38 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.37 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.37 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 3/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | TEK | Q02763 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25937545 | 0.94 | KCNQ2 (0.46) | KCNQ2USP30SIGMAR1RIPK1RORC | |
| SCHEMBL30557580 | 0.94 | KCNQ2 (0.46) | KCNQ2USP30SIGMAR1RIPK1RORC | |
| SCHEMBL25937779 | 0.86 | KDR (0.43) | USP30SIGMAR1RIPK1LCKMET | |
| SCHEMBL25937565 | 0.85 | KCNQ2 (0.40) | KCNQ2SIGMAR1RIPK1POLBDUSP3 | |
| SCHEMBL25937424 | 0.84 | NOTUM (0.53) | SIGMAR1ALDH1A1 | |
| SCHEMBL25937866 | 0.84 | TP53 (0.40) | SIGMAR1POLBTDP1RORC | |
| SCHEMBL27983431 | 0.84 | MAPT (0.41) | USP30ALDH1A1 | |
| SCHEMBL25937726 | 0.83 | DPP8 (0.40) | KCNQ2SIGMAR1MEN1ALDH1A1TSHR | |
| SCHEMBL25429865 | 0.83 | DGAT1 (0.42) | KCNQ2DGAT1SOAT2SOAT1POLB | |
| SCHEMBL25937688 | 0.82 | SIGMAR1 (0.38) | KCNQ2SIGMAR1RORCMETMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023144793-A1 | POL THETA INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-08-03 | — | — | WO | disclosed |
| WO-2023144793-A1 | POL THETA INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-08-03 | — | — | WO | disclosed |