Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 15/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | EZH1 | Q92800 | 7/20 | 0.40 |
| ▸ | EED | O75530 | 2/20 | 0.40 |
| ▸ | RBBP4 | Q09028 | 2/20 | 0.40 |
| ▸ | SUZ12 | Q15022 | 2/20 | 0.40 |
| ▸ | RBBP7 | Q16576 | 2/20 | 0.40 |
| ▸ | AEBP2 | Q6ZN18 | 2/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.38 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2594802 | 0.76 | EZH2 (0.72) | EZH2EZH1EEDRBBP4SUZ12 | |
| SCHEMBL2595663 | 0.75 | RIPK1 (0.51) | EZH2PARP1 | |
| SCHEMBL2594853 | 0.74 | LRRK2 (0.42) | EZH2EZH1EEDRBBP4SUZ12 | |
| SCHEMBL30350272 | 0.71 | EZH2 (0.63) | EZH2EZH1EEDRBBP4SUZ12 | |
| SCHEMBL12682122 | 0.69 | JAK1 (0.57) | JAK1JAK3 | |
| SCHEMBL2587384 | 0.69 | EZH2 (0.50) | EZH2JAK1JAK3PARP1 | |
| SCHEMBL28074535 | 0.66 | PIK3CA (0.42) | JAK1JAK3PARP1 | |
| SCHEMBL30810190 | 0.66 | BCAT2 (0.53) | PARP1 | |
| SCHEMBL12682095 | 0.66 | JAK1 (0.60) | JAK1JAK3 | |
| SCHEMBL2592470 | 0.65 | MAP4K1 (0.45) | EZH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566328-A1 | INDAZOLES | GlaxoSmithKline LLC (US) | 2013-03-13 | — | — | EP | claimed |
| WO-2011140325-A1 | INDAZOLES | GLAXOSMITHKLINE LLC (US) | 2011-11-10 | — | — | WO | claimed |