Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.42 |
| ▸ | EZH2 | Q15910 | 13/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | EZH1 | Q92800 | 5/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | EED | O75530 | 1/20 | 0.35 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.35 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.35 |
| ▸ | RBBP7 | Q16576 | 1/20 | 0.35 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2594243 | 0.89 | KDM4E (0.46) | LRRK2EZH2EZH1GSK3BDYRK1A | |
| SCHEMBL2593480 | 0.87 | IRAK4 (0.41) | LRRK2EZH2EZH1GSK3BDYRK1A | |
| SCHEMBL2595663 | 0.75 | RIPK1 (0.51) | LRRK2EZH2PARP1PIK3CAMTOR | |
| SCHEMBL2594617 | 0.74 | EZH2 (0.44) | EZH2PARP1EZH1EEDRBBP4 | |
| SCHEMBL2595562 | 0.71 | EZH2 (0.80) | EZH2EZH1EEDRBBP4SUZ12 | |
| SCHEMBL30350272 | 0.71 | EZH2 (0.63) | LRRK2EZH2EZH1EEDRBBP4 | |
| SCHEMBL2588507 | 0.71 | MTOR (0.38) | LRRK2PIK3CAMTORGSK3BDYRK1A | |
| SCHEMBL2587384 | 0.70 | EZH2 (0.50) | EZH2PARP1KDM4E | |
| SCHEMBL14716614 | 0.70 | LRRK2 (0.34) | LRRK2PIK3CAMTORGSK3BDYRK1A | |
| SCHEMBL2592086 | 0.69 | ROCK2 (0.40) | LRRK2PIK3CAMTORGSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566328-A1 | INDAZOLES | GlaxoSmithKline LLC (US) | 2013-03-13 | — | — | EP | claimed |
| WO-2011140325-A1 | INDAZOLES | GLAXOSMITHKLINE LLC (US) | 2011-11-10 | — | — | WO | claimed |