Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNMT | Q14749 | 2/20 | 0.66 |
| ▸ | AHCY | P23526 | 7/20 | 0.66 |
| ▸ | NADK | O95544 | 1/20 | 0.66 |
| ▸ | DOT1L | Q8TEK3 | 3/20 | 0.60 |
| ▸ | DNMT3B | Q9UBC3 | 2/20 | 0.60 |
| ▸ | PNMT | P11086 | 1/20 | 0.60 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.60 |
| ▸ | DPP4 | P27487 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.59 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.59 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.59 |
| ▸ | GAPDH | P04406 | 1/20 | 0.59 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.59 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.59 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.59 |
| ▸ | STAT6 | P42226 | 1/20 | 0.59 |
| ▸ | PI4KA | P42356 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18572517 | 1.00 | GNMT (0.66) | GNMTAHCYNADKDOT1LDNMT3B | |
| SCHEMBL22683278 | 1.00 | GNMT (0.66) | GNMTAHCYNADKDOT1LDNMT3B | |
| SCHEMBL6905922 | 1.00 | GNMT (0.66) | GNMTAHCYNADKDOT1LDNMT3B | |
| SCHEMBL22683279 | 0.85 | GNMT (0.76) | GNMTAHCYNADKDOT1LDNMT3B | |
| SCHEMBL18572516 | 0.85 | GNMT (0.76) | GNMTAHCYNADKDOT1LDNMT3B | |
| SCHEMBL18572550 | 0.85 | GNMT (0.76) | GNMTAHCYNADKDOT1LDNMT3B | |
| SCHEMBL6893100 | 0.85 | AHCY (0.70) | GNMTAHCYNADKDOT1LDNMT3B | |
| Adenosine SCHEMBL1128079 | 0.83 | ADORA3 (0.74) | GNMTAHCYNADKDOT1LDPP4 | |
| SCHEMBL6908163 | 0.81 | AHCY (0.76) | AHCYNADKDOT1LDNMT3BPNMT | |
| SCHEMBL6908804 | 0.80 | AHCY (0.69) | GNMTAHCYNADKDOT1LDNMT3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219496-A1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN Pharmaceutica NV (BE) | 2023-08-02 | — | — | EP | disclosed |