Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHCY | P23526 | 7/20 | 0.69 |
| ▸ | NADK | O95544 | 1/20 | 0.69 |
| ▸ | DOT1L | Q8TEK3 | 3/20 | 0.63 |
| ▸ | DNMT3B | Q9UBC3 | 2/20 | 0.63 |
| ▸ | PNMT | P11086 | 1/20 | 0.63 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.63 |
| ▸ | GNMT | Q14749 | 2/20 | 0.63 |
| ▸ | DPP4 | P27487 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.62 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.62 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.62 |
| ▸ | GAPDH | P04406 | 1/20 | 0.62 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.62 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.62 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.62 |
| ▸ | STAT6 | P42226 | 1/20 | 0.62 |
| ▸ | PI4KA | P42356 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7060100 | 0.88 | AHCY (0.66) | AHCYNADKDOT1LDNMT3BPNMT | |
| SCHEMBL7171951 | 0.88 | AHCY (0.66) | AHCYNADKDOT1LDNMT3BPNMT | |
| SCHEMBL29804034 | 0.86 | GNMT (0.70) | AHCYNADKDOT1LDNMT3BPNMT | |
| SCHEMBL6900787 | 0.85 | GNMT (0.69) | AHCYNADKDOT1LDNMT3BPNMT | |
| SCHEMBL6908433 | 0.84 | AHCY (0.72) | AHCYNADKDOT1LDNMT3BPNMT | |
| SCHEMBL6893100 | 0.83 | AHCY (0.70) | AHCYNADKDOT1LDNMT3BPNMT | |
| SCHEMBL6907796 | 0.83 | GNMT (0.76) | AHCYNADKDOT1LDNMT3BPNMT | |
| SCHEMBL6908163 | 0.83 | AHCY (0.76) | AHCYNADKDOT1LDNMT3BPNMT | |
| Methylthioadenosine SCHEMBL890628 | 0.82 | AHCY (0.83) | AHCYNADKDOT1LDNMT3BPNMT | |
| Methylthioadenosine SCHEMBL20798030 | 0.82 | AHCY (0.83) | AHCYNADKDOT1LDNMT3BPNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040043959-A1 | Combination therapies for treating methylthioadenosine phosphorylase deficient cells | AGOURON PHARMACEUTICALS INC. | 2004-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040043959-A1 | Combination therapies for treating methylthioadenosine phosphorylase deficient cells | APRT, MTAP, TYMP | AHCY 62/4885NADK 1514/4885DOT1L 1250/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.