SCHEMBL259468

SCHEMBL259468

Cc1cccc(NC(=O)c2ccccc2)c1

nearest known ligand 0.87

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNK3 O14649 9/20 0.87
KCNK9 Q9NPC2 7/20 0.87
MEN1 O00255 5/20 0.87
KMT2A Q03164 5/20 0.87
POLB P06746 1/20 0.87
RXFP1 Q9HBX9 1/20 0.83
KCNH2 Q12809 1/20 0.77
RAB9A P51151 6/20 0.69
SMN1; SMN2 Q16637 3/20 0.69
NPC1 O15118 3/20 0.69
TP53 P04637 2/20 0.69
NFKB1 P19838 1/20 0.69
NFKB2 Q00653 1/20 0.69
RELA Q04206 1/20 0.69
ALDH1A1 P00352 3/20 0.69
MAPT P10636 4/20 0.67
HTT P42858 2/20 0.67
SIRT1 Q96EB6 1/20 0.67
L3MBTL1 Q9Y468 2/20 0.65
APAF1 O14727 1/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29434800 1.00 KCNK3 (0.87) KCNK3KCNK9MEN1KMT2APOLB
SCHEMBL12922066 0.94 KCNK3 (0.77) KCNK3KCNK9MEN1KMT2APOLB
SCHEMBL4253897 0.91 KCNK3 (0.93) KCNK3KCNK9MEN1KMT2APOLB
SCHEMBL10090678 0.90 KMT2A (0.72) KCNK3KCNK9MEN1KMT2APOLB
SCHEMBL8461683 0.90 MEN1 (0.73) KCNK3KCNK9MEN1KMT2APOLB
SCHEMBL259706 0.89 MEN1 (0.77) KCNK3KCNK9MEN1KMT2APOLB
SCHEMBL259666 0.89 KCNK3 (0.87) KCNK3KCNK9MEN1KMT2APOLB
SCHEMBL30608967 0.89 KCNK3 (0.87) KCNK3KCNK9MEN1KMT2APOLB
SCHEMBL2908619 0.89 MEN1 (0.89) KCNK3KCNK9MEN1KMT2APOLB
Dimethylamine SCHEMBL9292692 0.87 MEN1 (0.69) KCNK3KCNK9MEN1KMT2APOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 70 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3303291-A1 ROR GAMMA (ROR ) MODULATORS Lead Pharma Holding B.V. (NL) 2018-04-11 EP claimed
WO-2016193452-A1 ROR GAMMA (RORγ) MODULATORS LEAD PHARMA CEL MODELS IP B.V. (NL) 2016-12-08 WO claimed
EP-0620122-B1 Thermosensitive recording material NEW OJI PAPER CO LTD (JP) 1996-03-13 EP claimed
US-5446010-A Substrate sheet, thermosensitive colored image forming layer containing colorless dye precursor, binder, color developing agent having sulfonylureido group, aromatic amide sensitizer; storage stability NEW OJI PAPER CO., LTD. (JP) 1995-08-29 US claimed
EP-0620122-A1 Thermosensitive recording material NEW OJI PAPER CO., LTD. (JP) 1994-10-19 EP claimed
US-20250179031-A1 PROTEASOME ENHANCERS AND USES THEREOF BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY 2025-06-05 US disclosed
WO-2024050825-A1 COMPOUNDS AS MLKL INHIBITORS NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) 2024-03-14 WO disclosed
WO-2024044778-A2 NOVEL MODULATORS OF FSHR AND USES THEREOF CELMATIX INC. (US) 2024-02-29 WO disclosed
CN-115057794-B Method for removing methylation of cerium catalytic oxidation amide by visible light induction 桂林理工大学 2023-11-17 CN disclosed
WO-2023147485-A2 PROTEASOME ENHANCERS AND USES THEREOF BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) 2023-08-03 WO disclosed
WO-2023073115-A1 PROTEIN AGGREGATION INHIBITING COMPOUNDS FOR PLANT DISEASE CONTROL MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 2023-05-04 WO disclosed
US-20220388953-A1 COMPOUNDS WITH ANTIMICROBIAL ACTIVITY THE HONG KONG POLYTECHNIC UNIVERSITY (CN) 2022-12-08 US disclosed
US-20070037805-A1 Fused heteroaryl derivatives HAYAKAWA MASAHIKO 2007-02-15 US disclosed
US-7173029-B2 Fused heteroaryl derivatives ASTELLAS PHARMA INC. (JP) 2007-02-06 US disclosed
US-7173029-B2 Fused heteroaryl derivatives ASTELLAS PHARMA INC. (JP) 2007-02-06 US disclosed
EP-1453828-A2 AZABICYCLIC COMPOUNDS FOR THE TREATMENT OF FIBROMYALGIA SYNDROME AstraZeneca AB (SE) 2004-09-08 EP disclosed
WO-2003032897-A2 AZABICYCLIC COMPOUNDS FOR THE TREATMENT OF FIBROMYALGIA SYNDROME ASTRAZENECA AB (SE) 2003-04-24 WO disclosed
EP-0620122-B1 Thermosensitive recording material NEW OJI PAPER CO LTD (JP) 1996-03-13 EP disclosed
US-5446010-A Substrate sheet, thermosensitive colored image forming layer containing colorless dye precursor, binder, color developing agent having sulfonylureido group, aromatic amide sensitizer; storage stability NEW OJI PAPER CO., LTD. (JP) 1995-08-29 US disclosed
EP-0620122-A1 Thermosensitive recording material NEW OJI PAPER CO., LTD. (JP) 1994-10-19 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250179031-A1 PROTEASOME ENHANCERS AND USES THEREOF PSME3, PSMG3, PSME1 KCNK3 4081/4885KCNK9 4269/4885MEN1 4218/4885
US-20220388953-A1 COMPOUNDS WITH ANTIMICROBIAL ACTIVITY MPO, MRPL21, ELANE KCNK3 4402/4885KCNK9 3984/4885MEN1 3907/4885
US-20070037805-A1 Fused heteroaryl derivatives PIK3CD, PIK3R3, PIK3C2A KCNK3 1197/4885KCNK9 1798/4885MEN1 3330/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.