Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | NSD2 | O96028 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16418634 | 0.74 | CA2 (0.38) | ALDH1A1MAPTPOLBKDM4ENSD2 | |
| SCHEMBL27192110 | 0.73 | ALDH1A1 (0.39) | ALDH1A1MAPTPOLBKDM4ENSD2 | |
| SCHEMBL26352926 | 0.73 | ALDH1A1 (0.34) | ALDH1A1MAPTPOLBKDM4ENSD2 | |
| SCHEMBL29303159 | 0.70 | ALDH1A1 (0.33) | ALDH1A1MAPTPOLBKDM4ENSD2 | |
| SCHEMBL27035863 | 0.70 | ALDH1A1 (0.33) | ALDH1A1MAPTPOLBKDM4ENSD2 | |
| SCHEMBL23514455 | 0.70 | JAK2 (0.31) | ALDH1A1MAPTKDM4ENSD2 | |
| SCHEMBL15870925 | 0.68 | ALDH1A1 (0.31) | ALDH1A1MAPTPOLB | |
| SCHEMBL24858186 | 0.68 | MET (0.35) | ALDH1A1MAPTMETKDM4ENSD2 | |
| SCHEMBL29304911 | 0.68 | ALDH1A1 (0.31) | ALDH1A1MAPTPOLB | |
| SCHEMBL21672135 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230271939-A1 | 4-ETHYNYLPYRIDINE DERIVATIVES USEFUL AS GCN2 INHIBITORS | IP2IPO INNOVATIONS LIMITED (GB) | 2023-08-31 | — | — | US | disclosed |
| US-20230250082-A1 | 4-ETHYNYLPYRIDINE DERIVATIVES USEFUL AS GCN2 INHIBITORS | IP2IPO INNOVATIONS LIMITED (GB) | 2023-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230271939-A1 | 4-ETHYNYLPYRIDINE DERIVATIVES USEFUL AS GCN2 INHIBITORS | EIF2AK4, GCN1, EIF5B | ALDH1A1 2504/4885MAPT 4473/4885POLB 2508/4885 |
| US-20230250082-A1 | 4-ETHYNYLPYRIDINE DERIVATIVES USEFUL AS GCN2 INHIBITORS | EIF2AK4, GCN1, EIF5B | ALDH1A1 2504/4885MAPT 4473/4885POLB 2508/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.