Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.50 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | AR | P10275 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | GBA1 | P04062 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | PGR | P06401 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7572313 | 0.88 | CA12 (0.59) | ALDH1A1MEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL7571617 | 0.88 | TAAR1 (0.56) | ALDH1A1MEN1KMT2AHTTPKM | |
| SCHEMBL7573869 | 0.87 | MEN1 (0.54) | ALDH1A1MEN1KMT2AHTTTBXA2R | |
| SCHEMBL7570427 | 0.84 | AR (0.57) | ALDH1A1MEN1KMT2AHTTLMNA | |
| SCHEMBL7570456 | 0.84 | MEN1 (0.51) | ALDH1A1MEN1KMT2AHTTKDM4E | |
| SCHEMBL411104 | 0.81 | ALDH1A1 (0.79) | ALDH1A1MEN1KMT2AHTTKDM4E | |
| SCHEMBL7580123 | 0.81 | PGR (0.57) | ALDH1A1MEN1KMT2AHTTLMNA | |
| SCHEMBL1880968 | 0.80 | ALDH1A1 (0.72) | ALDH1A1MEN1KMT2AHTTKDM4E | |
| SCHEMBL1876555 | 0.79 | ALDH1A1 (0.71) | ALDH1A1MEN1KMT2AHTTKDM4E | |
| SCHEMBL19280574 | 0.78 | ALDH1A1 (0.56) | ALDH1A1KEAP1KDM4ELMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563770-A1 | BIARYL PHOSPHODIESTERASE INHIBITORS | Leo Pharma A/S (DK) | 2013-03-06 | — | — | EP | disclosed |
| WO-2011134468-A1 | BIARYL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA A/S (DK) | 2011-11-03 | — | — | WO | disclosed |