Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 7/20 | 0.44 |
| ▸ | CDK4 | P11802 | 5/20 | 0.44 |
| ▸ | CDK1 | P06493 | 2/20 | 0.44 |
| ▸ | INSR | P06213 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
| ▸ | FLT4 | P35916 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | CDK7 | P50613 | 1/20 | 0.44 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.44 |
| ▸ | PI4KA | P42356 | 3/20 | 0.41 |
| ▸ | PI4K2B | Q8TCG2 | 3/20 | 0.41 |
| ▸ | PI4K2A | Q9BTU6 | 3/20 | 0.41 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.41 |
| ▸ | TTK | P33981 | 3/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5356546 | 0.98 | AURKA (0.43) | AURKACDK4CDK1INSRPDGFRB | |
| SCHEMBL2241217 | 0.92 | MKNK2 (0.41) | AURKACDK4CDK1INSRPDGFRB | |
| SCHEMBL12984555 | 0.81 | DGAT1 (0.42) | AURKACDK4MKNK2DGAT1PRMT5 | |
| SCHEMBL28122201 | 0.79 | ABL1 (0.42) | CDK1INSRSRCFLT4KDR | |
| SCHEMBL25956967 | 0.79 | ALDH1A1 (0.38) | AURKACDK4CDK1INSRPDGFRB | |
| SCHEMBL25047342 | 0.77 | PRMT5 (0.39) | SRCKDRMKNK2PRMT5WDR77 | |
| SCHEMBL25047326 | 0.76 | ALDH1A1 (0.46) | PI4KAPI4K2BPI4K2API4KBMKNK2 | |
| SCHEMBL24110237 | 0.76 | MKNK2 (0.39) | CDK4MKNK2PRMT5WDR77 | |
| SCHEMBL25049095 | 0.76 | PRMT5 (0.36) | INSRPDGFRBSRCPDGFRAFLT1 | |
| SCHEMBL27575145 | 0.76 | DRD2 (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219496-A1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN Pharmaceutica NV (BE) | 2023-08-02 | — | — | EP | disclosed |