Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | FLT1 | P17948 | 5/20 | 0.43 |
| ▸ | KDR | P35968 | 5/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | AHR | P35869 | 1/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22257201 | 0.89 | NPC1 (0.58) | NPC1RAB9AL3MBTL1LMNASMN1; SMN2 | |
| SCHEMBL25958469 | 0.88 | FLT1 (0.45) | NPC1RAB9AL3MBTL1FLT1KDR | |
| SCHEMBL25958463 | 0.85 | FLT1 (0.43) | NPC1RAB9AL3MBTL1FLT1KDR | |
| SCHEMBL25958459 | 0.85 | POLB (0.49) | NPC1RAB9AL3MBTL1LMNANFKB1 | |
| SCHEMBL25958481 | 0.84 | NPC1 (0.43) | NPC1RAB9AL3MBTL1FLT1KDR | |
| SCHEMBL25958707 | 0.82 | NPC1 (0.45) | NPC1RAB9AL3MBTL1FLT1KDR | |
| SCHEMBL25958688 | 0.82 | NPC1 (0.45) | NPC1RAB9AL3MBTL1FLT1KDR | |
| SCHEMBL22257192 | 0.80 | ALOX15 (0.59) | NPC1RAB9ALMNARIPK1 | |
| SCHEMBL25958305 | 0.80 | L3MBTL1 (0.46) | NPC1RAB9AL3MBTL1FLT1KDR | |
| SCHEMBL25958418 | 0.79 | NPC1 (0.45) | NPC1RAB9AL3MBTL1FLT1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230248752-A1 | PRODRUGS OF ALOX-15 INHIBITORS AND METHODS OF USING THE SAME | EMPIRICO INC. | 2023-08-10 | — | — | US | disclosed |
| US-11666588-B2 | Prodrugs of ALOX-15 inhibitors and methods of using the same | EMPIRICO INC. (US) | 2023-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230248752-A1 | PRODRUGS OF ALOX-15 INHIBITORS AND METHODS OF USING THE SAME | ALOX15, ALOX5, ALOX15B | NPC1 2279/4885RAB9A 4106/4885L3MBTL1 2134/4885 |
| US-11666588-B2 | Prodrugs of ALOX-15 inhibitors and methods of using the same | ALOX15, ALOX5, ALOX15B | NPC1 2279/4885RAB9A 4106/4885L3MBTL1 2134/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.