Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 4/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25959437 | 0.75 | IRAK4 (0.39) | CHEK1IRAK4AR | |
| SCHEMBL24056640 | 0.59 | CHEK1 (0.49) | CHEK1 | |
| SCHEMBL25555781 | 0.57 | GABRA1 (0.37) | CHEK1 | |
| SCHEMBL22448681 | 0.57 | LMNA (0.38) | CHEK1 | |
| SCHEMBL31633801 | 0.57 | GPR6 (0.37) | CHEK1IRAK4LRRK2 | |
| SCHEMBL18266146 | 0.56 | PDE2A (0.39) | — | |
| SCHEMBL30773928 | 0.56 | MBOAT4 (0.37) | IRAK4AR | |
| SCHEMBL22023351 | 0.56 | MBOAT4 (0.37) | IRAK4AR | |
| SCHEMBL25144387 | 0.56 | GABRP (0.36) | CHEK1LRRK2AR | |
| SCHEMBL3107926 | 0.56 | UHRF1 (0.54) | CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3870582-B1 | 5-AZAINDAZOLE DERIVATIVES AS ADENOSINE RECEPTOR ANTAGONISTS | MERCK PATENT GMBH (DE) | 2023-07-19 | — | — | EP | disclosed |