Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NQO2 | P16083 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2589897 | 0.88 | ALDH1A1 (0.48) | SMN1; SMN2ALDH1A1MAPTLMNANPC1 | |
| SCHEMBL14965715 | 0.85 | TAAR1 (0.54) | ALDH1A1MAPTLMNACYP2D6L3MBTL1 | |
| SCHEMBL2595478 | 0.85 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1MAPTLMNANPC1 | |
| SCHEMBL19175434 | 0.82 | LMNA (0.44) | SMN1; SMN2ALDH1A1MAPTLMNANPC1 | |
| SCHEMBL9280470 | 0.82 | TDP1 (0.44) | SMN1; SMN2ALDH1A1MAPTLMNANPC1 | |
| SCHEMBL16117976 | 0.82 | LMNA (0.47) | SMN1; SMN2ALDH1A1MAPTLMNANPC1 | |
| SCHEMBL6573968 | 0.81 | RAB9A (0.55) | CHEK1SMN1; SMN2ALDH1A1MAPTLMNA | |
| SCHEMBL19180992 | 0.81 | RAB9A (0.46) | SMN1; SMN2ALDH1A1MAPTLMNANPC1 | |
| SCHEMBL14971342 | 0.81 | CTSD (0.39) | SMN1; SMN2ALDH1A1MAPTLMNANPC1 | |
| SCHEMBL14965352 | 0.80 | CYP1A2 (0.52) | SMN1; SMN2ALDH1A1MAPTLMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8716287-B2 | Pharmaceutical compounds | SENTINEL ONCOLOGY LIMITED (GB) | 2014-05-06 | — | — | US | disclosed |
| CN-103038221-A | Chk-1 activity regulator | SENTINEL ONCOLOGY LTD | 2013-04-10 | — | — | CN | disclosed |
| EP-2569290-A2 | PHARMACEUTICAL COMPOUNDS | Sentinel Oncology Limited (GB) | 2013-03-20 | — | — | EP | disclosed |
| US-20130065900-A1 | PHARMACEUTICAL COMPOUNDS | SENTINEL ONCOLOGY LIMITED (GB) | 2013-03-14 | — | — | US | disclosed |
| WO-2011141716-A2 | PHARMACEUTICAL COMPOUNDS | SENTINEL ONCOLOGY LIMITED (GB) | 2011-11-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130065900-A1 | PHARMACEUTICAL COMPOUNDS | CSNK1A1, FRK, CSNK1E | CHEK1 105/4885SMN1; SMN2 3053/4885ALDH1A1 3289/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.