Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | SUV39H2 | Q9H5I1 | 3/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.40 |
| ▸ | ITGB7 | P26010 | 2/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14774797 | 0.94 | ITGA4 (0.42) | MAPTLMNAALDH1A1SMN1; SMN2HTT | |
| SCHEMBL2593352 | 0.85 | MAPT (0.49) | MAPTLMNAALDH1A1SMN1; SMN2HTT | |
| SCHEMBL14965496 | 0.82 | EPHX2 (0.44) | MAPTLMNASUV39H2EPHX2 | |
| SCHEMBL2593353 | 0.81 | MAPT (0.51) | MAPTLMNAALDH1A1SMN1; SMN2HTT | |
| SCHEMBL2596258 | 0.78 | LMNA (0.47) | MAPTLMNAALDH1A1SMN1; SMN2HTT | |
| SCHEMBL2589948 | 0.77 | CHEK1 (0.63) | — | |
| SCHEMBL2596237 | 0.76 | ALDH1A1 (0.46) | MAPTLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL29508963 | 0.75 | MAPT (0.52) | MAPTLMNAALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL22858566 | 0.75 | MAPT (0.52) | MAPTLMNAALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL310369 | 0.74 | MAPT (0.65) | MAPTLMNAALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011141716-A2 | PHARMACEUTICAL COMPOUNDS | SENTINEL ONCOLOGY LIMITED (GB) | 2011-11-17 | — | — | WO | disclosed |