Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.63 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.63 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.63 |
| ▸ | FER | P16591 | 1/20 | 0.63 |
| ▸ | LTK | P29376 | 1/20 | 0.63 |
| ▸ | CDK8 | P49336 | 1/20 | 0.63 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.63 |
| ▸ | MAOA | P21397 | 1/20 | 0.57 |
| ▸ | MAOB | P27338 | 1/20 | 0.57 |
| ▸ | GSK3B | P49841 | 1/20 | 0.56 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.56 |
| ▸ | ROS1 | P08922 | 1/20 | 0.55 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | CASP2 | P42575 | 1/20 | 0.48 |
| ▸ | CASP7 | P55210 | 1/20 | 0.48 |
| ▸ | CASP6 | P55212 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27425410 | 0.82 | LRRK2 (0.74) | LRRK2ACVR1PDGFRAFERLTK | |
| SCHEMBL2420711 | 0.82 | LRRK2 (0.90) | LRRK2ACVR1PDGFRAFERLTK | |
| SCHEMBL366728 | 0.82 | — | — | |
| SCHEMBL11879510 | 0.82 | ACVR1 (0.52) | LRRK2ACVR1PDGFRAFERLTK | |
| SCHEMBL27980501 | 0.78 | LRRK2 (0.82) | LRRK2ACVR1PDGFRAFERLTK | |
| SCHEMBL1368292 | 0.78 | LRRK2 (1.00) | LRRK2ACVR1PDGFRAFERLTK | |
| SCHEMBL16306322 | 0.77 | ACVR1 (0.65) | LRRK2ACVR1PDGFRAFERLTK | |
| SCHEMBL9653269 | 0.77 | ACVR1 (0.65) | LRRK2ACVR1PDGFRAFERLTK | |
| SCHEMBL8507659 | 0.76 | CSNK1G1 (0.72) | LRRK2ACVR1PDGFRAFERLTK | |
| Hydrochloric Acid SCHEMBL6299954 | 0.76 | LRRK2 (0.95) | LRRK2ACVR1PDGFRAFERLTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3788032-B1 | COMPOUNDS COMPRISING A LINKER FOR INCREASING TRANSCYCLOOCTENE STABILITY | TAGWORKS PHARMACEUTICALS B V (NL) | 2024-01-24 | — | — | EP | disclosed |
| WO-2023141856-A1 | CD3-TARGETING MULTISPECIFIC ANTIBODY AND USE THEREOF | 岩唐生物科技(杭州)有限责任公司 | 2023-08-03 | — | — | WO | disclosed |