Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 2/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.30 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.30 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2596743 | 0.81 | TGFBR1 (0.39) | TGFBR1 | |
| SCHEMBL2596838 | 0.78 | TGFBR1 (0.44) | TGFBR1AURKAJAK1AURKB | |
| SCHEMBL2596981 | 0.72 | TGFBR1 (0.36) | PTPN11TGFBR1LRRK2 | |
| SCHEMBL2596807 | 0.71 | JAK2 (0.32) | FFAR1PTPN11TGFBR1TLR7CYP3A4 | |
| SCHEMBL2598413 | 0.70 | LRRK2 (0.39) | FFAR1LRRK2TLR7 | |
| SCHEMBL2596820 | 0.65 | L3MBTL1 (0.30) | — | |
| SCHEMBL31586708 | 0.65 | PTPN11 (0.35) | FFAR1PTPN11LRRK2TLR7ADORA2A | |
| SCHEMBL30291299 | 0.64 | FFAR1 (0.52) | FFAR1LRRK2ALOX5APFEN1PDK2 | |
| SCHEMBL15651075 | 0.63 | ADORA2A (0.42) | FFAR1LRRK2TLR7ADORA2A | |
| SCHEMBL26388984 | 0.63 | FFAR1 (0.36) | FFAR1LRRK2ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011146287-A1 | PYRAZOLO[4,3-B]PYRIDINE-7-AMINE INHIBITORS OF ALK5 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-11-24 | — | — | WO | disclosed |