Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.45 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 2/20 | 0.45 |
| ▸ | ACE | P12821 | 1/20 | 0.44 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SCN1A | P35498 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20253879 | 0.96 | KMT2A (0.46) | KMT2ACHRNB2CHRNA5CHRNA7CHRNA4 | |
| SCHEMBL23746785 | 0.85 | ALDH1A1 (0.49) | KMT2ACHRNB2CHRNA5CHRNA7CHRNA4 | |
| SCHEMBL18849795 | 0.85 | ALDH1A1 (0.49) | KMT2ACHRNB2CHRNA5CHRNA7CHRNA4 | |
| SCHEMBL18474161 | 0.85 | ALDH1A1 (0.49) | KMT2ACHRNB2CHRNA5CHRNA7CHRNA4 | |
| SCHEMBL18474217 | 0.83 | DPP4 (0.45) | KMT2ACHRNB2CHRNA5CHRNA7CHRNA4 | |
| SCHEMBL18474160 | 0.83 | DPP4 (0.45) | KMT2ACHRNB2CHRNA5CHRNA7CHRNA4 | |
| SCHEMBL19099852 | 0.83 | KMT2A (0.44) | KMT2ATSHRKCNH2MAPTMAOA | |
| SCHEMBL20253880 | 0.81 | TDP1 (0.45) | KMT2ACHRNB2CHRNA5CHRNA7CHRNA4 | |
| SCHEMBL8911799 | 0.80 | LTA4H (0.49) | KMT2ATSHRLTA4HFKBP1AALOX5 | |
| SCHEMBL7026294 | 0.80 | LTA4H (0.49) | KMT2ATSHRLTA4HFKBP1AALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3810129-B1 | PCSK9 ANTAGONIST BICYCLO-COMPOUNDS | MERCK SHARP & DOHME LLC (US) | 2023-08-16 | — | — | EP | disclosed |