Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MPI | P34949 | 1/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 2/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.36 |
| ▸ | VNN1 | O95497 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1753882 | 0.68 | LTA4H (0.46) | MPOALDH1A1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL17713797 | 0.68 | LTA4H (0.46) | MPOPOLBALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL28166476 | 0.66 | ALDH1A1 (0.46) | MPOPOLBALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL27585502 | 0.64 | NPSR1 (0.44) | POLBALDH1A1SMN1; SMN2LMNALTA4H | |
| SCHEMBL27298346 | 0.64 | LTA4H (0.53) | MPOALDH1A1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL8376680 | 0.63 | DHFR (0.76) | LMNA | |
| SCHEMBL28212221 | 0.63 | SLC2A1 (0.52) | MPOALDH1A1KDM4EMPIAPOBEC3G | |
| SCHEMBL7716578 | 0.63 | PLA2G7 (0.48) | MPOPOLBALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL27884 | 0.63 | LTA4H (0.81) | ALDH1A1SMN1; SMN2LMNALTA4H | |
| SCHEMBL25986524 | 0.63 | LTA4H (0.81) | ALDH1A1SMN1; SMN2LMNALTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011146287-A1 | PYRAZOLO[4,3-B]PYRIDINE-7-AMINE INHIBITORS OF ALK5 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-11-24 | — | — | WO | disclosed |