Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | KIF11 | P52732 | 1/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.31 |
| ▸ | CCNK | O75909 | 1/20 | 0.31 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL789216 | 0.91 | SLC6A9 (0.34) | BRD4CDK2GPR119 | |
| SCHEMBL2597109 | 0.87 | SLC6A9 (0.37) | BRD4F10CDK2GPR119 | |
| SCHEMBL789053 | 0.81 | SCN9A (0.32) | — | |
| SCHEMBL2597088 | 0.80 | F10 (0.31) | F10 | |
| SCHEMBL789299 | 0.80 | DPP4 (0.30) | — | |
| Hydrochloric Acid SCHEMBL14917661 | 0.80 | BRD4 (0.35) | BRD4GPR119HTR2CHTR2B | |
| SCHEMBL789678 | 0.77 | SCN9A (0.33) | F10CDK9 | |
| SCHEMBL15105353 | 0.72 | FPR2 (0.39) | BRD4GAAKIF11F10GPR119 | |
| SCHEMBL790390 | 0.72 | FPR2 (0.39) | BRD4GAAKIF11F10GPR119 | |
| SCHEMBL789192 | 0.70 | GPR119 (0.40) | BRD4GPR119HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616074-A1 | PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS | Array Biopharma, Inc. (US) | 2013-07-24 | — | — | EP | disclosed |
| WO-2012037393-A1 | PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS | ARRAY BIOPHARMA INC. (US) | 2012-03-22 | — | — | WO | disclosed |