SCHEMBL25976228

SCHEMBL25976228

CCNC(=O)C(Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)CCCCCNC(C)(O)CC

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 1/20 0.46
CHRNB4 P30926 1/20 0.46
CHRNA3 P32297 1/20 0.46
CHRNA4 P43681 1/20 0.46
FAAH O00519 2/20 0.46
HDAC3 O15379 1/20 0.43
HDAC4 P56524 1/20 0.43
HDAC1 Q13547 1/20 0.43
HDAC7 Q8WUI4 1/20 0.43
HDAC2 Q92769 1/20 0.43
HDAC10 Q969S8 1/20 0.43
HDAC11 Q96DB2 1/20 0.43
HDAC8 Q9BY41 1/20 0.43
HDAC6 Q9UBN7 1/20 0.43
HDAC9 Q9UKV0 1/20 0.43
HDAC5 Q9UQL6 1/20 0.43
PSMB5 P28074 1/20 0.43
MMP1 P03956 2/20 0.42
MMP3 P08254 2/20 0.42
MMP8 P22894 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25976092 0.86 NPC1 (0.42) FAAHHDAC3HDAC4HDAC1HDAC7
SCHEMBL25976421 0.83 PSMB5 (0.49) CHRNB2CHRNB4CHRNA3CHRNA4FAAH
SCHEMBL17128773 0.83 CHRNB2 (0.56) CHRNB2CHRNB4CHRNA3CHRNA4FAAH
SCHEMBL16485202 0.83 CHRNB2 (0.56) CHRNB2CHRNB4CHRNA3CHRNA4FAAH
SCHEMBL17178170 0.83 CHRNB2 (0.52) CHRNB2CHRNB4CHRNA3CHRNA4FAAH
SCHEMBL25497019 0.82 FAAH (0.60) CHRNB2CHRNB4CHRNA3CHRNA4FAAH
SCHEMBL17177757 0.81 CHRNB2 (0.55) CHRNB2CHRNB4CHRNA3CHRNA4CHRNA1
SCHEMBL27377994 0.79 PSMB5 (0.51) FAAHHDAC3HDAC4HDAC1HDAC7
SCHEMBL25887442 0.78 HDAC3 (0.53) CHRNB2CHRNB4CHRNA3CHRNA4FAAH
SCHEMBL25975485 0.78 AKT1 (0.50) CHRNB2CHRNB4CHRNA3CHRNA4FAAH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4223318-A1 ANTITUMOR COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF Duality Biologics (Suzhou) Co., Ltd. (CN) 2023-08-09 EP disclosed