Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.56 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.56 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.56 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.56 |
| ▸ | MMP2 | P08253 | 1/20 | 0.55 |
| ▸ | CHRND | Q07001 | 8/20 | 0.54 |
| ▸ | CHRNA1 | P02708 | 4/20 | 0.54 |
| ▸ | CHRNG | P07510 | 4/20 | 0.54 |
| ▸ | CHRNB1 | P11230 | 4/20 | 0.54 |
| ▸ | FAAH | O00519 | 2/20 | 0.51 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.51 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.51 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17128773 | 1.00 | CHRNB2 (0.56) | CHRNB2CHRNB4CHRNA3CHRNA4MMP2 | |
| SCHEMBL17029474 | 0.93 | CHRNB2 (0.54) | CHRNB2CHRNB4CHRNA3CHRNA4MMP2 | |
| SCHEMBL17177757 | 0.92 | CHRNB2 (0.55) | CHRNB2CHRNB4CHRNA3CHRNA4MMP2 | |
| SCHEMBL25874361 | 0.90 | MMP2 (0.56) | CHRNB2CHRNB4CHRNA3CHRNA4MMP2 | |
| SCHEMBL16485208 | 0.90 | MMP2 (0.60) | MMP2CHRNDCHRNA1CHRNGCHRNB1 | |
| SCHEMBL25497019 | 0.88 | FAAH (0.60) | CHRNB2CHRNB4CHRNA3CHRNA4FAAH | |
| SCHEMBL25976421 | 0.85 | PSMB5 (0.49) | CHRNB2CHRNB4CHRNA3CHRNA4CHRND | |
| SCHEMBL27377994 | 0.85 | PSMB5 (0.51) | FAAH | |
| SCHEMBL17178170 | 0.85 | CHRNB2 (0.52) | CHRNB2CHRNB4CHRNA3CHRNA4CHRND | |
| SCHEMBL16485165 | 0.84 | CHRNA1 (0.54) | CHRNB2CHRNB4CHRNA3CHRNA4MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015155998-A1 | ANTI-HER3 ANTIBODY-DRUG CONJUGATE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2015-10-15 | — | — | WO | disclosed |
| WO-2014057687-A1 | ANTIBODY-DRUG CONJUGATE | 第一三共株式会社 (JP) | 2014-04-17 | — | — | WO | disclosed |