Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE2 | O96020 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.37 |
| ▸ | SLC26A6 | Q9BXS9 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.37 |
| ▸ | NCF1 | P14598 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CASP6 | P55212 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30462002 | 0.86 | CCNE2 (0.43) | CCNE2CCNE1CDK2SMN1; SMN2LMNA | |
| SCHEMBL26627877 | 0.86 | CCNE2 (0.43) | CCNE2CCNE1CDK2SMN1; SMN2LMNA | |
| SCHEMBL29133952 | 0.84 | CCNE2 (0.55) | CCNE2CCNE1CDK2LMNA | |
| SCHEMBL30661275 | 0.84 | CCNE2 (0.55) | CCNE2CCNE1CDK2LMNA | |
| SCHEMBL25976929 | 0.78 | SLC26A6 (0.41) | L3MBTL1SLC26A6PDE3BPDE3AP2RY12 | |
| SCHEMBL26627837 | 0.77 | PDE4A (0.44) | CCNE2CCNE1CDK2SMN1; SMN2LMNA | |
| SCHEMBL15584951 | 0.76 | APP (0.55) | LMNAKDM4ERAB9A | |
| SCHEMBL25976268 | 0.76 | KDM4E (0.41) | CCNE1CDK2SMN1; SMN2KDM4E | |
| SCHEMBL3646724 | 0.71 | LMNA (0.39) | LMNAL3MBTL1 | |
| SCHEMBL29019899 | 0.70 | CCNE2 (0.57) | CCNE2CCNE1CDK2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023148643-A1 | FUSED BICYCLIC HETEROCYCLYL COMPOUNDS AS USP1 INHIBITORS | AURIGENE ONCOLOGY LIMITED (IN) | 2023-08-10 | — | — | WO | disclosed |