Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE2 | O96020 | 1/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | PDE5A | O76074 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | USP1 | O94782 | 1/20 | 0.37 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26627877 | 1.00 | CCNE2 (0.43) | CCNE2CCNE1CDK2PDE5AMEN1 | |
| SCHEMBL25976265 | 0.86 | CCNE2 (0.40) | CCNE2CCNE1CDK2KDM4ESMN1; SMN2 | |
| SCHEMBL29976549 | 0.85 | CCNE2 (0.56) | CCNE2CCNE1CDK2PDE5AMEN1 | |
| SCHEMBL1442298 | 0.79 | PDE5A (0.53) | PDE5AMEN1KMT2AKDM4EMAPK1 | |
| SCHEMBL31423660 | 0.78 | USP1 (0.65) | USP1WDR48 | |
| SCHEMBL30462058 | 0.78 | PDE5A (0.49) | CCNE2CCNE1CDK2PDE5A | |
| SCHEMBL29043876 | 0.78 | PDE5A (0.49) | CCNE2CCNE1CDK2PDE5A | |
| SCHEMBL25976929 | 0.77 | SLC26A6 (0.41) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL26627837 | 0.75 | PDE4A (0.44) | CCNE2CCNE1CDK2PDE5APOLB | |
| SCHEMBL31423575 | 0.75 | RORC (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118660872-A | Pyrimidine compound, preparation method and medical application thereof | 江苏亚虹医药科技股份有限公司 | 2024-09-17 | — | — | CN | disclosed |
| CN-116496252-A | Pyrimidine compound, preparation method and medical application thereof | 江苏亚虹医药科技股份有限公司 | 2023-07-28 | — | — | CN | disclosed |