SCHEMBL25976340

SCHEMBL25976340

O=CCCC(=O)N1CCC(c2ccccc2)=N1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.47
RAB9A P51151 3/20 0.47
SMN1; SMN2 Q16637 3/20 0.47
HPGD P15428 1/20 0.47
L3MBTL1 Q9Y468 2/20 0.47
HCRTR1 O43613 1/20 0.47
CASP3 P42574 1/20 0.47
SENP8 Q96LD8 1/20 0.47
SENP7 Q9BQF6 1/20 0.47
SENP6 Q9GZR1 1/20 0.47
PGR P06401 7/20 0.43
CYP1A2 P05177 1/20 0.43
CYP2C9 P11712 1/20 0.43
CYP2C19 P33261 1/20 0.43
MAPT P10636 4/20 0.42
MAPK1 P28482 2/20 0.42
NPC1 O15118 2/20 0.42
KDM4E B2RXH2 1/20 0.42
GLA P06280 1/20 0.42
TDP1 Q9NUW8 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1033103 0.80 RAB9A (0.70) ALDH1A1RAB9ASMN1; SMN2HPGDL3MBTL1
SCHEMBL981651 0.78 ALDH1A1 (0.50) ALDH1A1RAB9ASMN1; SMN2HPGDL3MBTL1
SCHEMBL9234149 0.74 PGR (0.50) ALDH1A1RAB9ASMN1; SMN2HPGDL3MBTL1
SCHEMBL982457 0.74 MAOB (0.49) ALDH1A1RAB9ASMN1; SMN2HPGDL3MBTL1
SCHEMBL979412 0.74 ALDH1A1 (0.54) ALDH1A1RAB9ASMN1; SMN2HPGDL3MBTL1
SCHEMBL979242 0.70 ALDH1A1 (0.56) ALDH1A1RAB9ASMN1; SMN2HPGDL3MBTL1
SCHEMBL12922889 0.70 MAOB (0.50) ALDH1A1RAB9ASMN1; SMN2HPGDL3MBTL1
SCHEMBL13983177 0.69 PGR (0.54) ALDH1A1RAB9ASMN1; SMN2HPGDL3MBTL1
SCHEMBL18334695 0.68 MAOB (0.50) ALDH1A1RAB9AL3MBTL1CASP3SENP8
SCHEMBL984420 0.68 HCRTR1 (0.45) ALDH1A1RAB9ASMN1; SMN2HPGDL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023150639-A2 SMALL MOLECULE MODULATORS OF GTPASE ENZYMES AND USES THEREOF THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2023-08-10 WO disclosed