Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.70 |
| ▸ | HPGD | P15428 | 1/20 | 0.70 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.56 |
| ▸ | PGR | P06401 | 5/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL981651 | 0.83 | ALDH1A1 (0.50) | RAB9ASMN1; SMN2ALDH1A1HPGDHCRTR1 | |
| SCHEMBL25976340 | 0.80 | ALDH1A1 (0.47) | RAB9ASMN1; SMN2ALDH1A1HPGDHCRTR1 | |
| SCHEMBL9234149 | 0.79 | PGR (0.50) | RAB9ASMN1; SMN2ALDH1A1HPGDHCRTR1 | |
| SCHEMBL982457 | 0.79 | MAOB (0.49) | RAB9ASMN1; SMN2ALDH1A1HPGDHCRTR1 | |
| SCHEMBL980240 | 0.77 | MAOB (0.53) | RAB9ASMN1; SMN2ALDH1A1HPGDHCRTR1 | |
| SCHEMBL982974 | 0.76 | RAB9A (0.58) | RAB9ASMN1; SMN2ALDH1A1HPGDHCRTR1 | |
| SCHEMBL979242 | 0.75 | ALDH1A1 (0.56) | RAB9ASMN1; SMN2ALDH1A1HPGDHCRTR1 | |
| SCHEMBL12922889 | 0.75 | MAOB (0.50) | RAB9ASMN1; SMN2ALDH1A1HPGDHCRTR1 | |
| SCHEMBL981780 | 0.74 | ALDH1A1 (0.48) | RAB9ASMN1; SMN2ALDH1A1HPGDHCRTR1 | |
| SCHEMBL979286 | 0.74 | ALDH1A1 (0.71) | RAB9ASMN1; SMN2ALDH1A1HPGDL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7875644-B2 | tyrosine kinase inhibitors, in particular Met kinase; antitumor agents;1-(Benzo-1,2,5-thiadiazol-5-ylmethylcarbonyl)-3-(2,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole; leukemia, carcinomas | MERCK PATENT GMBH (DE) | 2011-01-25 | — | — | US | disclosed |
| US-20080249095-A1 | 1-Acyldihydropyrazole Derivatives | MERCK PATENT GESELLSCHAFT (DE) | 2008-10-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080249095-A1 | 1-Acyldihydropyrazole Derivatives | MET, FLT3, ERBB3 | RAB9A 2347/4885SMN1; SMN2 4245/4885ALDH1A1 399/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.