Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP1 | O94782 | 8/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30462082 | 0.93 | USP1 (0.42) | USP1CCNE2CCNE1CDK2PDE2A | |
| SCHEMBL29043898 | 0.93 | USP1 (0.42) | USP1CCNE2CCNE1CDK2PDE2A | |
| SCHEMBL25978629 | 0.90 | USP1 (0.40) | USP1CCNE2CCNE1CDK2PDE2A | |
| SCHEMBL25978768 | 0.87 | USP1 (0.39) | USP1HDAC1HDAC8HDAC6HDAC5 | |
| SCHEMBL29296027 | 0.87 | USP1 (0.39) | USP1HDAC1HDAC8HDAC6HDAC5 | |
| SCHEMBL29878992 | 0.87 | USP1 (0.39) | USP1HDAC1HDAC8HDAC6HDAC5 | |
| SCHEMBL30032845 | 0.87 | USP1 (0.39) | USP1HDAC1HDAC8HDAC6HDAC5 | |
| SCHEMBL27031623 | 0.87 | USP1 (0.39) | USP1HDAC1HDAC8HDAC6HDAC5 | |
| SCHEMBL30032988 | 0.87 | USP1 (0.39) | USP1HDAC1HDAC8HDAC6HDAC5 | |
| SCHEMBL27088234 | 0.87 | USP1 (0.39) | USP1HDAC1HDAC8HDAC6HDAC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023148643-A1 | FUSED BICYCLIC HETEROCYCLYL COMPOUNDS AS USP1 INHIBITORS | AURIGENE ONCOLOGY LIMITED (IN) | 2023-08-10 | — | — | WO | disclosed |