Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1B | Q01064 | 12/20 | 0.34 |
| ▸ | PDE1A | P54750 | 11/20 | 0.34 |
| ▸ | PDE1C | Q14123 | 10/20 | 0.34 |
| ▸ | CLK1 | P49759 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2598332 | 0.77 | TGFBR1 (0.37) | — | |
| SCHEMBL2598448 | 0.72 | TGFBR1 (0.40) | PDE1BPDE1APDE1CCLK1DYRK1A | |
| SCHEMBL2598467 | 0.70 | ADORA3 (0.38) | PDE1BPDE1APDE1C | |
| SCHEMBL21877826 | 0.70 | PDE1A (0.59) | PDE1BPDE1APDE1C | |
| SCHEMBL19269980 | 0.68 | PIK3CD (0.37) | PDE1BPDE1APDE1C | |
| SCHEMBL30369543 | 0.68 | PDE1B (0.52) | PDE1BPDE1APDE1C | |
| SCHEMBL17997562 | 0.68 | PDE1B (0.52) | PDE1BPDE1APDE1C | |
| SCHEMBL2598826 | 0.68 | JAK1 (0.30) | — | |
| SCHEMBL2598377 | 0.67 | MPO (0.35) | — | |
| SCHEMBL12725287 | 0.67 | DRD4 (0.33) | PDE1BPDE1APDE1CDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011146287-A1 | PYRAZOLO[4,3-B]PYRIDINE-7-AMINE INHIBITORS OF ALK5 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-11-24 | — | — | WO | disclosed |