Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.36 |
| ▸ | PDE1A | P54750 | 3/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.34 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CLK1 | P49759 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CCNK | O75909 | 1/20 | 0.31 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
| ▸ | XDH | P47989 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2598467 | 0.87 | ADORA3 (0.38) | TGFBR1PDE1APDE1BPDE1CPOLB | |
| SCHEMBL2598377 | 0.80 | MPO (0.35) | TGFBR1KDM4EALDH1A1 | |
| SCHEMBL2598326 | 0.79 | TTBK1 (0.33) | TGFBR1 | |
| SCHEMBL2598465 | 0.78 | TGFBR1 (0.39) | TGFBR1KDM4EALDH1A1 | |
| SCHEMBL2598357 | 0.77 | MAPK1 (0.33) | TGFBR1DYRK1AALDH1A1 | |
| SCHEMBL2598332 | 0.77 | TGFBR1 (0.37) | TGFBR1ALDH1A1POLB | |
| SCHEMBL2598351 | 0.75 | NPBWR1 (0.49) | KDM4EALDH1A1 | |
| SCHEMBL2598302 | 0.75 | DGAT1 (0.32) | — | |
| SCHEMBL2598306 | 0.72 | PDE1B (0.34) | PDE1APDE1BPDE1CCLK1DYRK1A | |
| SCHEMBL2598490 | 0.71 | ALDH1A1 (0.36) | KDM4EALDH1A1GAABLMCCNK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011146287-A1 | PYRAZOLO[4,3-B]PYRIDINE-7-AMINE INHIBITORS OF ALK5 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-11-24 | — | — | WO | disclosed |