Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX12 | P18054 | 15/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 1.00 |
| ▸ | RAB9A | P51151 | 8/20 | 0.74 |
| ▸ | NPC1 | O15118 | 7/20 | 0.74 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.74 |
| ▸ | MEN1 | O00255 | 3/20 | 0.74 |
| ▸ | LMNA | P02545 | 3/20 | 0.74 |
| ▸ | POLB | P06746 | 2/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.74 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.68 |
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.66 |
| ▸ | HTT | P42858 | 3/20 | 0.65 |
| ▸ | USP2 | O75604 | 1/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | KDM1A | O60341 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL609251 | 0.85 | ALOX12 (1.00) | ALOX12KDM4ERAB9ANPC1TDP1 | |
| SCHEMBL2153807 | 0.83 | ALOX12 (0.75) | ALOX12KDM4ERAB9ANPC1TDP1 | |
| SCHEMBL23792596 | 0.82 | ALOX12 (0.86) | ALOX12KDM4ERAB9ANPC1TDP1 | |
| SCHEMBL2153066 | 0.82 | ALOX12 (0.86) | ALOX12KDM4ERAB9ANPC1TDP1 | |
| SCHEMBL2598275 | 0.81 | KDM4E (1.00) | ALOX12KDM4ERAB9ANPC1TDP1 | |
| SCHEMBL2598265 | 0.80 | ALOX12 (1.00) | ALOX12KDM4ERAB9ANPC1TDP1 | |
| SCHEMBL24634616 | 0.80 | ALOX12 (0.77) | ALOX12KDM4ERAB9ANPC1TDP1 | |
| SCHEMBL30876646 | 0.80 | ALOX12 (0.77) | ALOX12KDM4ERAB9ANPC1TDP1 | |
| SCHEMBL2153098 | 0.80 | NPC1 (0.80) | ALOX12KDM4ERAB9ANPC1TDP1 | |
| SCHEMBL609894 | 0.80 | ALOX12 (1.00) | ALOX12KDM4ERAB9ANPC1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571853-A1 | INHIBITORS OF HUMAN 12-LIPOXYGENASE | The U.S.A. as represented by the Secretary, Department of Health and Human Services (US) | 2013-03-27 | — | — | EP | claimed |
| WO-2011146618-A1 | INHIBITORS OF HUMAN 12-LIPOXYGENASE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-11-24 | — | — | WO | claimed |
| US-20130096159-A1 | INHIBITORS OF HUMAN 12-LIPOXYGENASE | The United States of America, as represented the Secretary Department of Health & Human Service (US) | 2013-04-18 | — | — | US | disclosed |
| EP-2571853-A1 | INHIBITORS OF HUMAN 12-LIPOXYGENASE | The U.S.A. as represented by the Secretary, Department of Health and Human Services (US) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011146618-A1 | INHIBITORS OF HUMAN 12-LIPOXYGENASE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-11-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130096159-A1 | INHIBITORS OF HUMAN 12-LIPOXYGENASE | ALOX12, ALOX15B, ALOX15 | ALOX12 1/4885KDM4E 2798/4885RAB9A 2761/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.