Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24692266 | 0.83 | NR1H2 (0.37) | — | |
| SCHEMBL27120641 | 0.82 | SIGMAR1 (0.32) | SLC6A4KCNH2SIGMAR1 | |
| SCHEMBL27120437 | 0.80 | CHRM1 (0.36) | SLC6A4HRH3KCNH2SIGMAR1 | |
| SCHEMBL25993189 | 0.75 | KCNH2 (0.41) | KCNH2TMEM97SIGMAR1 | |
| SCHEMBL26418968 | 0.74 | HRH3 (0.49) | TLR7CYP2D6SRD5A1KDM4EALDH1A1 | |
| SCHEMBL27119471 | 0.73 | SIGMAR1 (0.33) | SLC6A4KCNH2SIGMAR1 | |
| SCHEMBL25986948 | 0.71 | NPC1 (0.31) | TLR7CYP2D6MAPTNPC1RAB9A | |
| SCHEMBL27121617 | 0.71 | SIGMAR1 (0.36) | SLC6A4HRH3KCNH2SIGMAR1 | |
| SCHEMBL21140748 | 0.69 | HRH3 (0.45) | TLR7SRD5A1KDM4EHRH3NPC1 | |
| SCHEMBL10066156 | 0.68 | MAOA (0.52) | TLR7SLC6A2SLC6A4SLC6A3HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3820573-B1 | 3-(5-HYDROXY-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF IKAROS FAMILY ZINC FINGER 2 (IKZF2)-DEPENDENT DISEASES | NOVARTIS AG (CH) | 2023-08-09 | — | — | EP | disclosed |