Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | ABHD6 | Q9BV23 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | PHGDH | O43175 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 5/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18281308 | 0.71 | — | — | |
| SCHEMBL9002612 | 0.70 | ACHE (0.40) | ALDH1A1ABHD6TSHRFAAHPHGDH | |
| SCHEMBL7449669 | 0.70 | — | — | |
| SCHEMBL304311 | 0.67 | ATM (0.46) | ALDH1A1ABHD6TSHRFAAHPHGDH | |
| SCHEMBL30169538 | 0.66 | ALDH1A1 (0.41) | ALDH1A1TSHRATMHPGDPOLB | |
| SCHEMBL304310 | 0.66 | FAAH (0.44) | ALDH1A1ABHD6TSHRFAAHPHGDH | |
| SCHEMBL24043005 | 0.65 | ATM (0.43) | ALDH1A1ABHD6TSHRFAAHPHGDH | |
| Hydrochloric Acid SCHEMBL11341920 | 0.64 | TSHR (0.42) | ALDH1A1ABHD6TSHRFAAHPHGDH | |
| SCHEMBL9357964 | 0.63 | TSHR (0.49) | ALDH1A1TSHRFAAHPHGDHMGLL | |
| SCHEMBL4552317 | 0.63 | HSD11B1 (0.44) | ALDH1A1ABHD6TSHRFAAHPHGDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571361-A1 | PYRAZOLOPYRIMIDINE COMPOUNDS FOR THE TREATMENT OF CANCER | The University of North Carolina At Chapel Hill (US) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011156698-A2 | NOVEL PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS | ABBOTT LABORATORIES (US) | 2011-12-15 | — | — | WO | disclosed |
| WO-2011146313-A1 | PYRAZOLOPYRIMIDINE COMPOUNDS FOR THE TREATMENT OF CANCER | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2011-11-24 | — | — | WO | disclosed |