Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 14/20 | 0.52 |
| ▸ | SLC6A4 known ✓ | P31645 | 8/20 | 0.52 |
| ▸ | CHRNB2 | P17787 | 14/20 | 0.52 |
| ▸ | CHRNB4 | P30926 | 14/20 | 0.52 |
| ▸ | CHRNA3 | P32297 | 14/20 | 0.52 |
| ▸ | CHRNA4 | P43681 | 14/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 14/20 | 0.52 |
| ▸ | CHRNA1 | P02708 | 13/20 | 0.52 |
| ▸ | CHRNB1 | P11230 | 13/20 | 0.52 |
| ▸ | CHRNG | P07510 | 10/20 | 0.52 |
| ▸ | CHRND | Q07001 | 10/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL2599506 | 1.00 | CHRNB2 (0.52) | CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL2599499 | 0.90 | CHRNB2 (0.61) | CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4 | |
| Fumaric Acid SCHEMBL2599548 | 0.86 | SLC6A2 (0.47) | CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4 | |
| Fumaric Acid SCHEMBL2599546 | 0.86 | SLC6A2 (0.47) | CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4 | |
| Fumaric Acid SCHEMBL2599572 | 0.86 | SLC6A2 (0.52) | CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4 | |
| Fumaric Acid SCHEMBL2599574 | 0.86 | SLC6A2 (0.52) | CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4 | |
| Radafaxine SCHEMBL5448768 | 0.81 | CHRNB2 (0.82) | CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4 | |
| Radafaxine SCHEMBL5448761 | 0.81 | CHRNB2 (0.82) | CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL2599505 | 0.77 | CHRNA1 (0.42) | CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL12186459 | 0.77 | CHRNB2 (0.59) | CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571858-B1 | PHENYLMORPHOLINES AND ANALOGUES THEREOF | RES TRIANGLE INST (US) | 2018-06-20 | — | — | EP | disclosed |
| US-9617229-B2 | Phenylmorpholines and analogues thereof | RESEARCH TRIANGLE INSTITUTE (US) | 2017-04-11 | — | — | US | disclosed |
| US-20130203752-A1 | PHENYLMORPHOLINES AND ANALOGUES THEREOF | NIH-DEITR | 2013-08-08 | — | — | US | disclosed |
| EP-2571858-A1 | PHENYLMORPHOLINES AND ANALOGUES THEREOF | Research Triangle Institute (US) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011146850-A1 | PHENYLMORPHOLINES AND ANALOGUES THEREOF | RESEARCH TRIANGLE INSTITUTE (US) | 2011-11-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130203752-A1 | PHENYLMORPHOLINES AND ANALOGUES THEREOF | PNMT, OPRL1, OPRM1 | SLC6A2 5/4885SLC6A4 6/4885CHRNB2 168/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.