Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 14/20 | 0.43 |
| ▸ | ATR | Q13535 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 4/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2599601 | 1.00 | PIK3C3 (0.43) | PIK3C3ATRMTORPIK3CDPIK3CA | |
| SCHEMBL2599606 | 1.00 | PIK3C3 (0.43) | PIK3C3ATRMTORPIK3CDPIK3CA | |
| SCHEMBL2597597 | 0.80 | DHFR (0.45) | MTORPIK3CA | |
| SCHEMBL16388793 | 0.78 | PIK3CA (0.37) | ATRMTORPIK3CDPIK3CA | |
| SCHEMBL2599581 | 0.77 | PIK3C3 (0.45) | PIK3C3ATRMTOR | |
| SCHEMBL16388498 | 0.76 | MTOR (0.37) | PIK3C3MTORPIK3CDPIK3CA | |
| SCHEMBL16388748 | 0.72 | PIK3C3 (0.48) | PIK3C3ATRPIK3CDPIK3CA | |
| SCHEMBL2599609 | 0.72 | PIK3C3 (0.48) | PIK3C3ATRMTORPIK3CDPIK3CA | |
| SCHEMBL14087877 | 0.72 | PIK3C3 (0.48) | PIK3C3MTORPIK3CA | |
| SCHEMBL2599611 | 0.72 | PIK3C3 (0.48) | PIK3C3ATRMTORPIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571872-B1 | COMPOUNDS | TREHERNE JOHNATHAN MARK (GB) | 2014-12-31 | — | — | EP | disclosed |
| EP-2571872-A1 | COMPOUNDS | BTG International Limited (GB) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011144578-A1 | COMPOUNDS | SENEXIS LIMITED (GB) | 2011-11-24 | — | — | WO | disclosed |