Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 19/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 15/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 5/20 | 0.37 |
| ▸ | RICTOR | Q6R327 | 3/20 | 0.35 |
| ▸ | RPTOR | Q8N122 | 3/20 | 0.35 |
| ▸ | MAPKAP1 | Q9BPZ7 | 3/20 | 0.35 |
| ▸ | MLST8 | Q9BVC4 | 3/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2599671 | 1.00 | PDE4B (0.39) | PDE4BMTORPIK3CAPIK3R1RICTOR | |
| SCHEMBL2599605 | 1.00 | PDE4B (0.39) | PDE4BMTORPIK3CAPIK3R1RICTOR | |
| SCHEMBL16388793 | 0.87 | PIK3CA (0.37) | MTORPIK3CAPIK3R1RICTORRPTOR | |
| SCHEMBL2599665 | 0.76 | PIK3CD (0.38) | PDE4BPIK3CGPIK3CDPIK3CB | |
| SCHEMBL16388498 | 0.76 | MTOR (0.37) | MTORPIK3CAPIK3R1PIK3CDPIK3C3 | |
| SCHEMBL2599612 | 0.74 | PIK3CD (0.36) | PDE4BPIK3CGPIK3CDPIK3CB | |
| SCHEMBL2599637 | 0.74 | APP (0.41) | PDE4BPIK3CGPIK3CDPIK3CB | |
| SCHEMBL2599656 | 0.73 | NAAA (0.40) | PIK3CGPIK3CDPIK3CB | |
| SCHEMBL16332713 | 0.73 | CYP17A1 (0.34) | PDE4BPIK3CGPIK3CDPIK3CB | |
| SCHEMBL2599603 | 0.72 | MAPT (0.40) | PIK3CGPIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571872-B1 | COMPOUNDS | TREHERNE JOHNATHAN MARK (GB) | 2014-12-31 | — | — | EP | claimed |
| EP-2571872-A1 | COMPOUNDS | BTG International Limited (GB) | 2013-03-27 | — | — | EP | claimed |
| WO-2011144578-A1 | COMPOUNDS | SENEXIS LIMITED (GB) | 2011-11-24 | — | — | WO | claimed |
| EP-2571872-B1 | COMPOUNDS | TREHERNE JOHNATHAN MARK (GB) | 2014-12-31 | — | — | EP | disclosed |
| EP-2571872-A1 | COMPOUNDS | BTG International Limited (GB) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011144578-A1 | COMPOUNDS | SENEXIS LIMITED (GB) | 2011-11-24 | — | — | WO | disclosed |