Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 7/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.40 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.40 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.40 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | GCK | P35557 | 1/20 | 0.39 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16344897 | 0.92 | LTA4H (0.55) | LTA4HTSHRPIN1MEN1NPC1 | |
| Diphenylether SCHEMBL3946529 | 0.78 | LTA4H (0.75) | LTA4HTSHRMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL754535 | 0.75 | LTA4H (0.55) | LTA4HTSHRSMN1; SMN2ALKBH1ALDH1A1 | |
| SCHEMBL2599589 | 0.74 | PIN1 (0.55) | TSHRPIN1MEN1NPC1RAB9A | |
| Dimethylamine SCHEMBL2599649 | 0.74 | SMN1; SMN2 (0.52) | MEN1NPC1RAB9AKMT2AGAA | |
| SCHEMBL12620325 | 0.73 | PIN1 (0.56) | PIN1MEN1NPC1RAB9AKMT2A | |
| SCHEMBL15578302 | 0.72 | MEN1 (0.46) | LTA4HTSHRMEN1KMT2AGAA | |
| SCHEMBL11544017 | 0.72 | KCNQ3 (0.56) | LTA4HTSHRMEN1NPC1RAB9A | |
| SCHEMBL19408509 | 0.71 | LTA4H (0.55) | LTA4HTSHRMEN1NPC1RAB9A | |
| SCHEMBL18960309 | 0.69 | LTA4H (0.46) | LTA4HTSHRGAASMN1; SMN2GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571872-B1 | COMPOUNDS | TREHERNE JOHNATHAN MARK (GB) | 2014-12-31 | — | — | EP | disclosed |
| EP-2571872-A1 | COMPOUNDS | BTG International Limited (GB) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011144578-A1 | COMPOUNDS | SENEXIS LIMITED (GB) | 2011-11-24 | — | — | WO | disclosed |