Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | RAB9A | P51151 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.52 |
| ▸ | RELA | Q04206 | 2/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1509577 | 0.91 | SMN1; SMN2 (0.61) | SMN1; SMN2RAB9ANPC1NFKB1NFKB2 | |
| SCHEMBL16161600 | 0.89 | RAB9A (0.58) | SMN1; SMN2RAB9ANPC1NFKB1NFKB2 | |
| SCHEMBL16225037 | 0.76 | CYP2A6 (0.50) | SMN1; SMN2RAB9ANPC1NFKB1NFKB2 | |
| SCHEMBL26262868 | 0.76 | MAP4K4 (0.61) | SMN1; SMN2RAB9ANPC1NFKB1NFKB2 | |
| Biphenyl SCHEMBL6943550 | 0.75 | ALDH1A1 (0.69) | SMN1; SMN2RAB9ANPC1ATMALDH1A1 | |
| SCHEMBL8098714 | 0.75 | NPC1 (0.35) | SMN1; SMN2RAB9ANPC1NFKB1NFKB2 | |
| Dimethylamine SCHEMBL2599651 | 0.74 | LTA4H (0.46) | SMN1; SMN2RAB9ANPC1ALDH1A1MEN1 | |
| SCHEMBL6407267 | 0.73 | NPSR1 (0.55) | SMN1; SMN2RAB9ANPC1NFKB1NFKB2 | |
| Biphenyl SCHEMBL27543986 | 0.72 | ALDH1A1 (0.64) | SMN1; SMN2RAB9ANPC1ATMALDH1A1 | |
| SCHEMBL1743253 | 0.72 | NPC1 (0.52) | SMN1; SMN2RAB9ANPC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571872-B1 | COMPOUNDS | TREHERNE JOHNATHAN MARK (GB) | 2014-12-31 | — | — | EP | disclosed |
| EP-2571872-A1 | COMPOUNDS | BTG International Limited (GB) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011144578-A1 | COMPOUNDS | SENEXIS LIMITED (GB) | 2011-11-24 | — | — | WO | disclosed |