Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ERN1 | O75460 | 3/20 | 0.38 |
| ▸ | PTPRC | P08575 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3614065 | 0.86 | ERN1 (0.51) | MAPTALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL1242705 | 0.79 | DRD1 (0.48) | MAPTALDH1A1LMNAKMT2ANPSR1 | |
| SCHEMBL10019959 | 0.78 | L3MBTL1 (0.39) | ALDH1A1LMNAMEN1KMT2AHTT | |
| SCHEMBL22269634 | 0.78 | DRD1 (0.47) | MAPTALDH1A1KMT2ANPSR1GAA | |
| SCHEMBL10019784 | 0.77 | CTSS (0.48) | MAPTALDH1A1LMNANPSR1HTT | |
| SCHEMBL2963995 | 0.77 | ALDH1A1 (0.55) | MAPTALDH1A1MEN1KMT2ANPSR1 | |
| SCHEMBL18003639 | 0.76 | ALDH1A1 (0.67) | MAPTALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL10019788 | 0.75 | LMNA (0.51) | MAPTALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL10010397 | 0.75 | LMNA (0.44) | MAPTALDH1A1LMNANPSR1HTT | |
| SCHEMBL19621837 | 0.75 | LMNA (0.44) | MAPTALDH1A1LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571356-A1 | SPIRO ISOXAZOLINE COMPOUNDS AS SSTR5 ANTAGONISTS | Merck Sharp & Dohme Corp. (US) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011146324-A1 | SPIRO ISOXAZOLINE COMPOUNDS AS SSTR5 ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2011-11-24 | — | — | WO | disclosed |