Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2600366 | 0.84 | P4HA1 (0.44) | ALDH1A1KDM4ERAB9AMEN1KMT2A | |
| SCHEMBL2128792 | 0.82 | DYRK3 (0.52) | HCRTR1ALDH1A1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL12911323 | 0.82 | DYRK3 (0.43) | ALDH1A1KDM4EMAPTSMN1; SMN2RAB9A | |
| SCHEMBL4060329 | 0.81 | CCNE1 (0.46) | HCRTR1ALDH1A1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL3192165 | 0.76 | ALK (0.43) | HCRTR1ALDH1A1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL811649 | 0.71 | CA12 (0.56) | ALDH1A1MAPTSMN1; SMN2RAB9AMEN1 | |
| SCHEMBL29800427 | 0.71 | CA12 (0.56) | ALDH1A1MAPTSMN1; SMN2RAB9AMEN1 | |
| SCHEMBL3445968 | 0.69 | CA1 (0.61) | ALDH1A1KDM4EMAPTSMN1; SMN2RAB9A | |
| SCHEMBL18093518 | 0.67 | ALPL (0.57) | MAPTRAB9AKMT2APOLBNPC1 | |
| SCHEMBL18104381 | 0.67 | CA12 (0.50) | ALDH1A1MAPTSMN1; SMN2RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120101132-A1 | New Substituted Oxindole Derivative | CLAESSON MARTINA (SE) | 2012-04-26 | — | — | US | disclosed |
| US-20090291982-A1 | New Substituted Oxindole Derivative 352 | ASTRAZENECA AB (SE) | 2009-11-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090291982-A1 | New Substituted Oxindole Derivative 352 | PYGL, GSK3A, GSK3B | HCRTR1 1755/4885ALDH1A1 1793/4885KDM4E 3111/4885 |
| US-20120101132-A1 | New Substituted Oxindole Derivative | PYGL, GSK3A, GSK3B | HCRTR1 1476/4885ALDH1A1 1877/4885KDM4E 3035/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.