Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 3/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | HTT | P42858 | 3/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | AHR | P35869 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.32 |
| ▸ | GMNN | O75496 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22648624 | 0.82 | ALDH1A1 (0.38) | ALDH1A1HSD17B10MAPK1TSHRTP53 | |
| SCHEMBL10138704 | 0.78 | PRKCI (0.50) | ALDH1A1HSD17B10MAPK1TSHRTP53 | |
| SCHEMBL14047389 | 0.78 | ALDH1A1 (0.33) | ALDH1A1HSD17B10MAPK1TSHRTP53 | |
| SCHEMBL24677812 | 0.77 | ALDH1A1 (0.34) | ALDH1A1HSD17B10MAPK1TSHRTP53 | |
| SCHEMBL1031031 | 0.76 | ALDH1A1 (0.56) | ALDH1A1HSD17B10MAPK1TSHRKDM4E | |
| SCHEMBL8935677 | 0.75 | ALDH1A1 (0.44) | ALDH1A1HSD17B10MAPK1TSHRTP53 | |
| SCHEMBL28549139 | 0.75 | MAPT (0.45) | ALDH1A1HSD17B10MAPK1TSHRTP53 | |
| SCHEMBL28549140 | 0.75 | MAPT (0.45) | ALDH1A1HSD17B10MAPK1TSHRTP53 | |
| SCHEMBL28177918 | 0.73 | PRKCI (0.38) | ALDH1A1HSD17B10MAPK1TSHRTP53 | |
| SCHEMBL14219285 | 0.73 | ALDH1A1 (0.54) | ALDH1A1TP53KDM4EKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230265098-A1 | ALKYNE QUINAZOLINE DERIVATIVES AS INHIBITORS OF ERBB2 | ENLIVEN INC. | 2023-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230265098-A1 | ALKYNE QUINAZOLINE DERIVATIVES AS INHIBITORS OF ERBB2 | ERBB2, ERBB3, CHEK2 | ESR1 461/4885ALDH1A1 2707/4885HSD17B10 2947/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.